H. Takaku, T. Ito, K. Imai
Jun 5, 1986
Citations
0
Influential Citations
17
Citations
Journal
Chemistry Letters
Abstract
The 3,4-dimethoxybenzyl group was introduced to the 2′-hydroxyl group by the reaction of nucleosides with 3,4-dimethoxybenzyl trichloroacetimidate or 3,4-dimethoxybenzyl bromide-NaH. Further, this group can be used as a protecting group for the O6-amide group of the guanine residue. The protected nucleosides are useful starting materials for the synthesis of oligoribonucleotides. The 3,4-dimethoxybenzyl group was removed rapidly from the oligoribonucleotides by treatment with oxidizing agents without any damage to the glycosidic bonds.