J. Kuszmann
Jun 1, 1979
Citations
0
Influential Citations
26
Citations
Journal
Carbohydrate Research
Abstract
Abstract For studying the structure-activity relationship of cytostatically active hexitol derivatives, 1,2:5,6-dianhydro-3,4-di- O -methyl-( 17 ), -ethyl-, -allyl-, and -pentyl- d -mannitol, as well as 1,2:5,6-dianhydro-3,4-di- O -methyl- l -iditol, -galactitol, and - d -glucitol were synthesized. In the synthesis of 17 , 2,5-di- O -acetyl-1,6-di- O -mesyl-3,4-di- O -methyl- d -mannitol was used as an intermediate that could be deacetylated to give 1,6-di- O -mesyl-3,4-di- O -methyl- d -mannitol, a compound that proved to be about ten times as active as 1,6-di- O -mesyl- d -mannitol (“Mannitol-Myleran”), a known cytostatic compound.