L. Hroch, M. Hrušková, Janina Schmitz
Jun 1, 2012
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0
Influential Citations
10
Citations
Journal
Synthesis
Abstract
Diethyl 2-alkyl-2-(benzyloxycarbonylamino)malonates were saponified, activated with oxalyl chloride, and treated with primary aromatic amines. This gave 3,5-disubstituted hydantoin-5-carboxamides. As second products, 2-alkyl-2-formamido- N 1 , N 3 -bis(aryl)malonamides were isolated. The formation of both types of products is expected to include a cyclization to 2-alkoxyoxazol-5(4 H )-ones, acting as precursor for the hydantoins, or a further transformation to N -carboxy anhydrides, their chloride-promoted ring opening, and subsequent conversion to give the bis(aryl)malonamides.