R. Perlman, I. Pastan
Mar 27, 1968
Citations
1
Influential Citations
133
Citations
Quality indicators
Journal
Biochemical and biophysical research communications
Abstract
Abstract Cyclic 3′,5′-adenosine monophosphate (cyclic 3′,5′-AMP) participates in the regulation of many metabolic pathways in animal tissues (Sutherland and Rall, 1960) . Cyclic 3′,5′-AMP is also found in Escherichia coli, where its function is unknown (Makman and Sutherland, 1965) . This paper reports that cyclic 3′,5′-AMP increases the differential rate of synthesis of two inducible enzymes, β-galactosidase and tryptophanase. When the synthesis of these enzymes is repressed by glucose and pyruvate respectively, cyclic 3′,5′-AMP restores their synthesis to normal levels. Cyclic 3′,5′-AMP fails to stimulate the rate of synthesis of the repressible enzyme alkaline phosphatase.