Saburo Muraoka, Hiroshi Terada
Aug 17, 1972
Citations
0
Influential Citations
56
Citations
Journal
Biochimica et biophysica acta
Abstract
Abstract 3,5-Di-tert-butyl-4-hydroxybenzylidenemalononitrile (SF 6847) was found to be one of the most powerful uncouplers of respiratory-chain phosphorylation ever reported. Structure-activity studies of the derivatives indicated the role of three functional groups in SF 6847: (1) the malononitrile group as an electron withdrawing group, which may cause uncoupling by interaction with a primary energy conservation site, (ii) a free hydroxyl group as an electron donator, and (iii) bulky tertiary butyl groups of hydrophobic character located at a certain spacial distance from the electron withdrawing center.