M. Mulvihill, Julie L. C. Kan, A. Cooke
May 15, 2006
Citations
0
Influential Citations
7
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
3-[6-(2-Dimethylamino-1-imidazol-1-yl-butyl)-naphthalen-2-yloxy]-2,2-dimethyl-propionic acid and analogs were designed and synthesized as highly potent and selective CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBAs), with demonstrated in vivo efficacy to increase the half-life of exogenous atRA.