G. A. Khutornenko, N. S. Panshina, S. V. Zhuravlev
2004
Citations
0
Influential Citations
3
Citations
Journal
Pharmaceutical Chemistry Journal
Abstract
In continuation of our investigations into the synthesis of substituted phenothiazines, in a search for pharmacologically active substances, we have synthesized 3,7-diamlno-10acetylphenothiazine as a starting material. This choice was considered advisable on the grounds that phenothiazine-2-carmamate esters substituted in the I0 position by aminopropionyl chains exhibit high pharmacological activity. Thus, methyl lO-(B-diethylaminopropionyl)phenothiazine-2-carbamate has a more pronounced antiarrhythmic action than quinidine and novocainamide [i]. Ethyl 10-(B-morpholinopropionyl)phenothiazine-2-carbamate has entered medical practice under the name of ethmozine as a drug for treating extrasystole, heart flutter, and auricular and paroxysmal tachycardia [2, 3].