M. Metwally, S. Shaaban, B. F. Abdel-Wahab
Aug 31, 2009
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Current Organic Chemistry
Abstract
This review deals with synthesis and reactions of 3-acetylindoles as well as their biological activities. The data published over the last few years on the methods of synthesis and chemical properties of 3-acetylindoles are reviewed here for the first time. 3-Acetylindole derivatives have been in the centre of at- tention of researchers over many years due to the high prac- tical value of these compounds, in the first place, the unusu- ally broad spectrum of biological activities. For example, 4- (1H-indol-3-yl)-2-hydroxy-4-oxobut-2-enoic acid was useful as anti-HIV agent, other compounds derived from 3-acetylindoles used in the treatment of gastrointestinal, car- diovascular and CNS disorders, and also used as HIV-1 inte- grase inhibitors. Despite this importance, 3-acetylindoles have not been previously reviewed. The main purpose of this review is to present a survey of the literature on 3- acetylindole's chemistry and provides useful and up-to-date data for medicinal chemists.