S. Athimoolam, S. Natarajan
Jan 26, 2007
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Acta Crystallographica Section E-structure Reports Online
Abstract
Nicotinic acid (pyridine-3-carboxylic acid), a B vitamin also known as niacin, is a lipid-lowering agent widely used to treat hypertriglyceridemia by the inhibition of lipolysis in adipose tissue. A nicotinic acid complex, viz. 5-methylpyrazine-2carboxylic acid 4-oxide, is a commonly used drug for hypercholesterolemia (Lorenzen et al., 2001). Many of its pharmacological properties are detailed in our previous publications (Athimoolam et al., 2005; Athimoolam & Rajaram, 2005a,b). A series of ionic crystals of nicotinic acid– inorganic/organic complexes were grown in our laboratory to study the characteristic features of nicotinic acid, surveyed from the Cambridge Structure Database (Version 5.27; Allen, 2002), viz., the twisting of the carboxyl group and hydrogenbonding extension through the N and O sites of the vitamin. In a continuation of this work, we report here the crystal structure of the title compound, (I).