R. Dolle, D. Hoyer, J. Rinker
Apr 22, 1997
Citations
0
Influential Citations
8
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
Abstract The 3-chloro-4-carboxamido-6-arylpyridazines are a novel class of interleukin-1β converting enzyme (ICE) inhibitor. These agents are irreversible inhibitors with pyridazine 23 possessing a k obs [I] = 355 M−1s−1. A structure-activity relationship for this non-peptide class of compounds and the putative mechanism for irreversible inactivation are described.