Sandhya Bawa, F. Ahmad, Suresh Kumar
Nov 5, 2009
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0
Influential Citations
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Journal
Molbank
Abstract
Abstract: A direct reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1 H -pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH 4 /I 2 as a reducing agent is described. The reaction was carried out in MeOH under neutral conditions at room temperature to give the secondary amine, 3-chloro-4-fluoro--{[3-(4-methoxyphenyl)-1- Nphenyl-1H -pyrazol-4-yl]methyl}aniline (3). Keywords: reductive amination; pyrazolylamine; NaBH 4 /I 2 1. Introduction The direct reductive amination of aldehydes and ketones with a metal hydride reagent is one of the most useful methods for the synthesis of secondary and tertiary amines [1–4]. Secondary amines and their derivatives constitute many biologically active molecules and are important intermediates in the synthesis of active pharmaceutical ingredients, dyes, and fine chemicals [5–7]. In continuation of our interest in the synthesis of heteroaryl amines [8], we report herein the reductive amination of 3-(4-methoxyphenyl)-1-phenyl-1 H -pyrazole-4-carbaldehyde 2 with 3-chloro-4-flouroaniline using NaBH