A. Abadi, H. Al-Khamees
Oct 1, 1998
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Influential Citations
9
Citations
Quality indicators
Journal
Archiv der Pharmazie
Abstract
Two series of 3‐cyano‐2(1H)‐oxopyridine and 3‐cyano‐2(1H)‐iminopyridine derivatives carrying various aryl substituents at position 4 and (4‐((7‐chloro or trifluoromethylquinol‐4‐yl)amino)phenyl) substituent at position 6 were synthesized and evaluated for their antitumor activity. Compounds 3f and 6d showed high selectivity towards leukemia cell lines with full panel median growth inhibition GI50 average sensitivity towards all cell lines (MG‐MID) at 7.9 and 19.7 μM and leukemia subpanel GI50 average sensitivity towards leukemia cell lines (MG‐MID) at 1.74 and 2.9 μM, respectively, also they exhibited full panel total growth inhibition TGI (MG‐MID) at 34.8 and 59.0 μM and leukemia subpanel TGI (MG‐MID) at 5.3 and 13.5 μM, respectively.