J. Edelson, C. G. Skinner, J. Ravel
Feb 1, 1959
Citations
0
Influential Citations
8
Citations
Journal
Archives of Biochemistry and Biophysics
Abstract
Abstract 3-Cyclohexene-1- dl -alanine was prepared by condensing 4-bromomethylcyclohexene and ethyl acetamidocyanoacetate, followed by hydrolysis of the resulting intermediate. The amino acid analog inhibited the growth of Leuconostoc dextranicum 8086, and its toxicity was competitively reversed by leucine (inhibition index = 100). Its inhibitory properties were correlated with the structure of the cyclohexene ring. The active form probably possesses the configuration in which carbons 1 and 6 are on opposite sides of the plane of carbons 2, 3, 4, and 5.