E. Enkvist, G. Raidaru, Angela Vaasa
Oct 1, 2007
Citations
0
Influential Citations
22
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Carbocyclic analogs of 3'-deoxyadenosine were synthesized as racemates and the resulting stereoisomers were separated by chromatography on a chiral column. The conjugation of obtained compounds with hexa-(D-arginine) via 6-aminohexanoic acid linker led to a highly potent inhibitor of several basophilic protein kinases with some selectivity towards cAMP-dependent protein kinase.