M. Cymborowski, M. Chruszcz, Z. Dauter
Apr 1, 2007
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Journal
Acta Crystallographica Section E-structure Reports Online
Abstract
The crystal structure of the title compound [systematic name: (S)-2-ammonio-3-(3-iodo-4-hydroxyphenyl)propanoate hemihydrate], C9H10INO3� 0.5H2O, is stabilized by ionic interactions and a hydrogen-bond network. The hydrogen bonds, involving a water molecule located on a twofold axis, form bridged layers of 3-iodo-l-tyrosine molecules. Comment 3-Iodo-l-tyrosine, of which the hemihydrate structure, (I) (Fig. 1), is reported here, and 3,5-diiodo-l-tyrosine are precursors in the biosynthesis of thyroid hormones. These hormones are very important for the growth and development of vertebrate organisms. Moreover, 3-iodo-l-tyrosine was found to be an inhibitor of tyrosine hydroxylase (Fitzpatrick, 1988, 1991), which catalyzes the first step in the biosynthesis of