Dmytro Ostrovskyi, V. Iaroshenko, Iftikhar Ali
2011
Citations
0
Influential Citations
5
Citations
Journal
Synthesis
Abstract
The reaction of 5-amino-1H-imidazoles with 3-methox- alylchromone provided a set of imidazo(4,5-b)pyridines (1-des- azapurines) bearing the CO2Me substituent at the a-position of the pyridine core. The corresponding acids were synthesized by subse- quent hydrolysis of the ester function. Being typical purine isos- teres, 1-desazapurines are considered to be potent pharmacophores, and are widely used in drug design and medicinal chemistry.