A. Leiherer, A. Muendlein, C. Saely
Jun 1, 2019
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Quality indicators
Journal
Diabetes
Abstract
The ceramide ratios Cer(d18:1/16:0)/Cer(d18:1/24:0), Cer(d18:1/18:0)/Cer(d18:1/24:0) and Cer(d18:1/24:1)/Cer(d18:1/24:0) have recently been reported to be associated with cardiovascular risk. Data on their power to predict cardiovascular events in patients with type 2 diabetes (T2DM) are sparse, and it is unknown whether they prospectively predict cardiovascular events independently from the presence of coronary artery disease (CAD) at baseline. These issues are addressed in the present study. We measured the above-mentioned serum ceramide ratios in a cohort of 894 patients in whom the presence of CAD was determined angiographically. Prospectively, we recorded cardiovascular events over a mean follow-up time of 9.2±3.2 years. At baseline, the ratios Cer(d18:1/16:0)/Cer(d18:1/24:0), Cer(d18:1/18:0)/Cer(d18:1/24:0) and Cer(d18:1/24:1)/Cer(d18:1/24:0) were significantly higher in T2DM patients (n=239) than in patients without T2DM (0.11 vs. 0.10, p=0.011; 0.46 vs. 0.39, p Disclosure A. Leiherer: None. A. Muendlein: None. C.H. Saely: None. R. Laaksonen: None. M. Laaperi: None. A. Vonbank: None. B. Larcher: None. A. Mader: None. P. Fraunberger: None. H. Drexel: None.