M. Aytemi̇r, T. Uzbay, D. Erol
Mar 1, 1999
Citations
0
Influential Citations
11
Citations
Quality indicators
Journal
Arzneimittelforschung
Abstract
Summary A number of 2-methyl/ethyl-3-hydroxy-4(1H)-pyridinones have been synthesized by reacting with 4-pyrones and primary aromatic amines in ethanol. Their structures were confirmed by microanalysis, IR and 1H-NMR spectral analysis. Possible analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing and carrageenan rat paw edema tests. All compounds exhibited higher analgesic activities than acetylsalicylic acid. 1-(2-Piperidinoethyl)-2-methyl-3-hydroxy-4-(1H)-pyridinone · 2HBr (1), l-[2-(1-methyl-3-hydroxy-4(1H)-pyridinone · 2HBr (3) and 1-[2-(1-ethyl-3-hydroxy-4(1H)-pyridinone · 2HBr (6) showed higher anti-inflammatory activities than indometacin.