J. Elliott, J. Castro, G. Chicchi
May 19, 2010
Citations
0
Influential Citations
2
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of novel 4,4-disubstituted cyclohexylamine based NK(1) antagonists is described. The effect of changes to the C(1)-C(4) relative stereochemistry on the cyclohexane ring and replacements for the flexible linker are discussed, leading to the identification of compounds with high affinity and good in vivo duration of action.