V. Summa, A. Petrocchi, V. Matassa
Oct 25, 2006
Citations
1
Influential Citations
90
Citations
Quality indicators
Journal
Journal of medicinal chemistry
Abstract
The dihydroxypyrimidine carboxamide 4a was discovered as a potent and selective HIV integrase strand transfer inhibitor. The optimization of physicochemical properties, pharmacokinetic profiles, and potency led to the identification of 13 in the dihydroxypyrimidine series and 18 in the N-methylpyrimidinone series having low nanomolar activity in the cellular HIV spread assay in the presence of 50% normal human serum and very good pharmacokinetics in preclinical species.