Shigeo Ueda, H. Terauchi, A. Yano
May 4, 2004
Citations
0
Influential Citations
32
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
In our search for a novel class of inducible nitric oxide synthase (iNOS) inhibitors, 1,3-oxazolidin-2-imine was found to weakly inhibit iNOS. Further modifications of this compound resulted in a remarkable increase in both the in vivo and in vitro inhibitory activity and selectivity for iNOS.