Irfan Shaikh, R. Jadeja, Rajesh K. Patel
Feb 4, 2021
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0
Influential Citations
10
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Quality indicators
Journal
ChemRN: Synthetic Inorganic Chemistry (Topic)
Abstract
Abstract Two novel 4-acylhydrazone-5-pyrazolones (L1=(Z)-N'-((4-chlorophenyl)(3-methyl-5-oxo-1-(p-tolyl)-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide and L2 = (Z)-N'-((4-chlorophenyl)(1-(3-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)methylene)benzohydrazide) were synthesized from 4-acyl-5-pyrazolone and benzoyl hydrazide and assessed for in silico and in vitro antimalarial activity. One binary zinc(II) complex 1 [Zn(L1)2]DMF was synthesized from L1. Two mixed ligands complexes 2 [Zn(L2)(bpy)(OAc)]EtOH and 3 [Zn(L2)(phen)(H2O)] were synthesized from L2 with 2,2′-bipyridine and 1, 10-phenanthroline respectively. Ligands and complexes were characterized by 1H NMR, FT-IR, UV-Vis, Single crystal X-ray diffraction and conductance measurement. All compounds displayed decent outcomes in in vitro antimalarial activity.