Matthäus Getlik, Brian J. Wilson, M. M. Morshed
May 23, 2013
Citations
0
Influential Citations
11
Citations
Journal
The Journal of organic chemistry
Abstract
The reaction of 3-halo-4-aminopyridines with acyl chlorides and triethylamine is described. The pyridin-4-yl α-substituted acetamide products were obtained in moderate to high yields. The presented rearrangement reaction, in which the presumed N-acylated intermediate reacts intramolecularly via nucleophilic aromatic substitution, results in a formal two-carbon insertion.