D. Postel, A. N. V. Nhien, P. Villa
Jan 22, 2001
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract 4-Amino-5- H -2,3-dihydroisothiazole-1,1-dioxide ring was attached to a monosaccharide ring system by carbanion-mediated sulfonate intramolecular cyclisation (CSIC) of either secondary or tertiary aminonitrilesulfonamide carbohydrate derivatives using NaH, Cs 2 CO 3 or BuLi as a base. These new bicyclic systems were used as glycone precursors of aza analogues of TSAO RT inhibitors. We report the first synthesis of an aza analogue of TSAO-m 3 T.