M. Gaul, Guozhang Xu, J. Kirkpatrick
Sep 1, 2007
Citations
0
Influential Citations
14
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF(3) expressed cell line. The structure-activity relationship of this class of compounds is described.