Shenlin Huang, Ronghua Li, K. Lamontagne
Mar 15, 2011
Citations
1
Influential Citations
9
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
A series of 4-aminopyrimidine-5-carbaldehyde oxime was discovered to have potent VEGFR-2 inhibitory activity. Described here are the chemistry for analogue synthesis and SAR study results. The PK properties, kinase profiling, and in vivo efficacy study for compound 4b are also discussed.