I. Ukrainets, S. Taran, O. A. Evtifeeva
Aug 1, 1993
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Journal
Chemistry of Heterocyclic Compounds
Abstract
Different approaches to the reaction of ethyl 1-R-4-hydroxy-2-quinolone-3-carboxylates with 2-aminopyridine were studied. It was found that the most rational of them is the thermolysis of equimolar amounts of the amine and the corresponding ester. Data on the analgesic and antiinflammatory activity of the amides synthesized are presented.