L. Méndez, V. Kouznetsov
2002
Citations
0
Influential Citations
2
Citations
Journal
Heterocyclic Communications
Abstract
6-Fluoroand 6,8-difluro-4-methyl-2-(3-pyridyl)-l,2,3,4-tetrahydroquinolines (5,6) and their respective quinolines (7,8) were obtained by a two or three step synthesis, starting from the corresponding aldimines (1,2) preformed from 4-fluoroor 2,4-difluoroanilines and 3-pyridinecarboxaldehyde via a sequence of reactions that included nucleophilic addition of Grignard reagents to the aldimines and an acid-mediated intramolecular cyclisation of the homoallylamines with fluorinated substituents (3,4).