Junya Ishida, K. Hattori*, Hirofumi Yamamoto
Oct 1, 2005
Citations
0
Influential Citations
37
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
We have shown that a 4-phenyl-1,2,3,6-tetrahydropyridine fragment plays an important role in improving inhibitory potency against poly(ADP-ribose) polymerase-1 (PARP-1). Various benzamide analogues linked with this fragment via alkyl spacers have been prepared and evaluated. As a result, some of them have been found to be highly potent PARP-1 inhibitors.