D. H. Kim, J. Ryoo
Jun 22, 1995
Citations
0
Influential Citations
11
Citations
Journal
Bioorganic & Medicinal Chemistry Letters
Abstract
(3R,4S)-3-Benzyl-4-(bromomethyl)oxetan-2-one is a novel type of fast acting alternate substrate inhibitor for α-chymotrypsin. The hydroxyl group that is generated during the turnover process appears to be responsible for the high stability of the acyl enzyme intermediate.