K. Juvale, M. Wiese
Nov 1, 2012
Citations
0
Influential Citations
56
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry letters
Abstract
We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.