O. Peeters, N. Blaton, C. J. Ranter
Jan 15, 1997
Citations
0
Influential Citations
2
Citations
Journal
Acta Crystallographica Section C-crystal Structure Communications
Abstract
The title compound, N-{[5-(4-fluorophenyl)-1,8-dimethyl-2,3-dihydro-1H-1,4-benzodiazepin-2-yl]methyl}-p-toluamide monohydrate, C 26 H 26 FN 3 O.H 2 O, a benzodiazepine derivative with κ-opioid activity, crystallizes as a hydrate with two almost identical molecules in the asymmetric unit. The observed conformation, stabilized by two hydrogen bonds involving the H 2 O molecule, is common for the 2-(acylaminomethyl)benzodiazepines. Hydrogen bonds between H 2 O molecules and amidic O atoms link the non-equivalent molecules, with formation of endless chains in the a direction.