A. Borisov, Volodymyr V. Voloshchuk, Maxim A. Nechayev
Jul 10, 2013
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Influential Citations
7
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Journal
Synthesis
Abstract
An approach to the derivatives of 5,6,7,8-tetrahydropyrido[4,3- c ]pyridazine, a lead-oriented scaffold with two diversity points, was developed. The method included five steps starting from the readily available 4-piperidone derivatives and allowed for the preparation of the target compounds in 32–35% overall yields. The key step of the sequence included one-pot solvent-free reaction of the corresponding 4-piperidone derivative, glyoxylic acid, and hydrazine.