A. Sukhorukov, A. V. Lesiv, Yulia A. Khomutova
Apr 1, 2008
Citations
0
Influential Citations
1
Citations
Journal
Synthesis
Abstract
[(5,6-Dihydro-4 H-1,2-oxazin-3-yl)methyl]malonates undergo a cascade transformation into substituted methyl 7-oxo-1-oxa-6-azaspiro[4.4]nonane-8-carboxylates under catalytic hydrogenation conditions over Raney nickel. A mechanistic scheme involving initial N-O bond cleavage with the formation of imines as key intermediates is suggested.