A. Cerletti, E. Rothlin
Oct 22, 1955
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Influential Citations
140
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Nature
Abstract
THE possibility that 5-hydroxytryptamine plays a part in abnormal mental processes has been discussed by Gaddum1 and by Woolley and Shaw2. The hypothesis is based on the findings that this substance is a natural constituent of nervous tissue, particularly of the brain3, and that certain of its actions are antagonized by lysergic acid diethylamide4, a drug which on oral application and in doses of only 0.5–1.0 µgm./kgm. produces pronounced psychic disturbances in normal human beings5. According to this hypothesis, the effects of lysergic acid diethylamide result from its antagonistic effect on the 5-hydroxytryptamine in the brain.