G. Richarme
Apr 26, 1985
Citations
0
Influential Citations
12
Citations
Journal
Biochimica et Biophysica Acta
Abstract
Abstract 5-Methoxyindole-2-carboxylic acid a known inhibitor of α-ketoacid dehydrogenases in animal cells inhibits the binding protein dependent transport of ribose galactose and maltose while not affecting the lactose permease and the phospho enol pyruvate-glucose phosphotransferase; inhibition of transport occurs before a significant decrease in ATP concentration, showing that inhibition of transport does not result from ATP depletion. The binding protein-ligand interaction is not seriously affected by 5-methoxyindole-2-carboxylic acid indicating that another component of these transport systems is probably implicated in the inhibition.