N. Nduka, S. Shall
Oct 16, 1980
Citations
0
Influential Citations
4
Citations
Journal
Biochemical and biophysical research communications
Abstract
Abstract 5-methylnicotinamide is an inhibitor of poly(ADP-ribose) synthetase, and it enhances the cytotoxicity of alkylating agents and of radiation in mouse lymphoma L1210 cells. We have isolated a spontaneous variant L1210 cell which shows increased resistance to 5-methylnicotinamide and has a reduced potentiation of cell-killing by methylnitrosourea and by γ-radiation. This observation is further evidence in support of the participation of (ADP-ribose) n in DNA excision repair and in cell survival. This variant may be of use in the molecular analysis of this component of DNA repair.