A. Palmer, G. Münch, C. Brehm
Feb 1, 2008
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Influential Citations
26
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Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
A series of novel 1H-pyrrolo[3,2-b]pyridines was prepared relying on a copper iodide catalyzed cyclization of 2-prop-1-ynylpyridin-3-amines. A structure-activity relationship was established focusing on the influence of the substitution pattern in position 1, 3, and 5 of the heterocycle on anti-secretory activity, lipophilicity, and pK(a) value. Some of the compounds proved to be potent inhibitors of the gastric acid pump.