Cheng Chun, Zhu Xuyang, Ya Wu
Dec 1, 2014
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0
Influential Citations
16
Citations
Journal
Journal of Molecular Catalysis A-chemical
Abstract
Abstract A water-soluble Bronsted acid, 5-sulfosalicylic acid, efficiently catalyzed the direct three-component Mannich reactions of cyclohexanone and 3-pentanone in pure water. 21 Examples of Mannich reactions were presented, which afforded the corresponding β-amino ketones with up to 97% yield and decent diastereoselectivities. The acid catalyst can be recycled as an aqueous solution for at least six times and the yield of the Mannich product remained over 90%.