I. Brown
1982
Citations
0
Influential Citations
16
Citations
Journal
The International Journal of Applied Radiation and Isotopes
Abstract
6-211At-Astato-2-methyl-1,4-naphthoquinol bis (disodium phosphate) has been prepared as a potential endoradiotherapeutic drug for metastatic malignant disease. Astatine-211 was introduced into the unsubstituted aromatic ring of 2-methyl-1,4-naphthoquinone via the 6-chloromercuriderivative; the 5-stage synthesis was completed within one half-life. Overall radiochemical efficiency ranged from 28–32%, with a specific activity 3.5–3.7 μCi μmol−1 from 200 μCi 211At.