S. Bromidge, Barbara Bertani, Manuela Borriello
Oct 15, 2008
Citations
0
Influential Citations
21
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
Investigation of a series 6-[2-(4-aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones has led to the discovery of potent 5-HT(1A/1B/1D) receptor antagonists with and without additional SerT affinity. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.