Fu Chun
2007
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Journal
Fine and Specialty Chemicals
Abstract
6,7-Dihydro-5H-cyclopenta[b] pyridine is mainly used in research works of pharmaceuticals, bactericide and antimicrobial, it is also used in synthesis of plant protection agent, synthetic resin, antioxidant and plastics. At present, it becomes a topic of general interest because it is being used as a side-chain in production of fourth generation Cefpirome. The methods used practically for preparation of 6,7-dihydro-5H-cyclopenta[b] pyridine are namely N-hydroxyphthaldiamide route, acrolein route and diethyl adipate route. In acrolein route the yield of 6,7-dihydro-5H-cyclopenta[b] pyridine can reach 87.4%, hence it has better development prospect.