S. Youssif
May 1, 2004
Citations
0
Influential Citations
13
Citations
Journal
Journal of Chemical Research
Abstract
The treatment of 1-benzyl-, or 1-methyl-6-chlorouracil (1a,b) with nucleophilic primary amines followed by nitrosation, reduction, formylation and dehydro-cyclisation lead to xanthines 5 and 7. While, the treatment of uracil 8 with aromatic aldehydes 9a–f leads to the formation of dipyrimidinopyridines 10a–f, reaction with formalin and primary amines gives pyrimidopyrimidines 11a–d via double Michael reactions.