Emanuela Sperlinga, P. Kosson, Z. Urbańczyk-Lipkowska
May 16, 2005
Citations
1
Influential Citations
10
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (6Htc) has been proposed as a rigid mimic of tyrosine conformation in opioid ligand-receptor complex. The significant receptor binding to mu and delta opioid receptors of respective analogues of deltorphin, dermorphin, and endomorphin with D,L-6Htc prove initial prediction.