U. Ungerstedt
Dec 1, 1968
Citations
46
Influential Citations
1,449
Citations
Quality indicators
Journal
European journal of pharmacology
Abstract
Abstract Intracerebral injection of 6-hydroxy-dopamine induced degeneration of central dopamine and noradrenaline neurons. Injection into the substantia nigra produced an anterograde degeneration of the whole nigro-neostriatal dopamine neuron system. This was associated with marked motor disturbances. It is suggested that intracerebral administration of 6-hydroxy-dopamine may be used as a tool for anatomical and functional studies on central monoamine neurons.