Yaozhong Xu
1998
Citations
1
Influential Citations
9
Citations
Journal
Tetrahedron
Abstract
Abstract A novel method is described for site-specific and chemical crosslinking of oligodeoxynucleotides containing 6-methylsulphoxypurine with cysteine or peptides containing cysteine. 6-Methylsulphoxy group on purine is stable in aqueous solution, but easily replaceable by the thiol group of cysteine and glutathione. A mechanism of the reaction is proposed, and potential applications are discussed with a focus on DNA-protein interactions.