S. Shilin, Illya Lenko, O. Shablykina
Dec 25, 2018
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Abstract
New indan-1-one derivatives (8 examples) with amino acid fragments were synthesized through the N-acylation of the amino acids by 2-(3-oxo-2,3-dihydro-1 H- inden-5-yloxy)acetic acid using the method of activated N -hydroxysuccinimide esters. To obtain corresponding methyl esters (2 examples) two ways were possible: the N -acylation of the amino acid methyl esters by 2-(3-oxo-2,3-dihydro-1 - inden-5-yloxy)acetic acid through the activated imidazole derivatives or methylation of the carboxylic function of preformed N -{[(1-oxoindan-6-yl)oxy]acetyl}amino acids.