K. Kondo, H. Ogawa, H. Yamashita
Aug 1, 1999
Citations
2
Influential Citations
89
Citations
Quality indicators
Journal
Bioorganic & medicinal chemistry
Abstract
We previously reported a series of benzazepine derivatives as orally active nonpeptide arginine vasopressin (AVP) V2 receptor antagonists. After the lead structure OPC-31260 was structurally evaluated and optimized, the introduction of the 7-Cl moiety on the benzazepine and 2-CH3 on the aminobenzoyl moiety enhanced its oral activity. The new AVP-V2 selective antagonist OPC-41061 was determined to be a potent and orally active agent.