Javier Nieto, C. Andrés, A. Pérez-Encabo
Aug 19, 2015
Citations
0
Influential Citations
10
Citations
Journal
Organic & biomolecular chemistry
Abstract
Enantiopure 1,4-oxazepane derivatives have been prepared by selenocyclofunctionalization of chiral 3-prenyl- and 3-cinnamyl-2-hydroxymethyl-substituted perhydro-1,3-benzoxazine derivatives. The 7-endo-cyclization occurs in high yields and diastereoselection. The regio- and stereochemistry of the cyclization products was dependent on the substitution pattern of the double bond, the nature of the hydroxyl group and the experimental conditions.