S. Bromidge, Barbara Bertani, Manuela Borriello
2009
Citations
0
Influential Citations
5
Citations
Journal
Bioorganic & medicinal chemistry letters
Abstract
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones have been identified as highly potent 5-HT(1A/B/D) receptor antagonists with and without additional SerT activity and a high degree of selectivity over hERG potassium channels. Modulation of the different target activities gave compounds with a range of profiles suitable for further in vivo characterization.